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Study of urinary acidification in patients with idiopathic hypocitraturia
Araújo, N. C; Rebelo, M. A. P.
Affiliation
  • Araújo, N. C; Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Disciplina de Nefrologia.
  • Rebelo, M. A. P; Universidade do Estado do Rio de Janeiro, Disciplina de Nefrologia, Hospital Universitário Pedro Ernesto.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;33(2): 205-10, Feb. 2000.
Article de En | LILACS | ID: lil-252295
Bibliothèque responsable: BR1.1
ABSTRACT
Hypocitraturia (HCit) is one of the most remarkable features of renal tubular acidosis, but an acidification defect is not seen in the majority of hypocitraturic patients, whose disease is denoted idiopathic hypocitraturia. In order to assess the integrity of urinary acidification mechanisms in hypocitraturic idiopathic calcium stone formers, we studied two groups of patients, hypocitraturic (HCit, N = 21, 39.5 + or - 11.5 years, 11 females and 10 males) and normocitraturic (NCit, N = 23, 40.2 + or - 11.7 years, 16 females and 7 males) subjects, during a short ammonium chloride loading test lasting 8 h. During the baseline period HCit patients showed significantly higher levels of titratable acid (TA). After the administration of ammonium chloride, mean urinary pH (3rd to 8th hour) and TA and ammonium excretion did not differ significantly between groups. Conversely, during the first hour mean urinary pH was lower and TA and ammonium excretion was higher in HCit. The enhanced TA excretion by HCit during the baseline period and during the first hour suggests that the phosphate buffer mechanism is activated. The earlier response in ammonium excretion by HCit further supports other evidence that acidification mechanisms react promptly. The present results suggest that in the course of lithiasic disease, hypocitraturia coexists with subtle changes in the excretion of hydrogen ions in basal situations
Sujet(s)
Texte intégral: 1 Indice: LILACS Sujet Principal: Acidose tubulaire rénale / Calculs urinaires / Acide citrique Type d'étude: Etiology_studies Limites du sujet: Adult / Female / Humans / Male langue: En Texte intégral: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Thème du journal: BIOLOGIA / MEDICINA Année: 2000 Type: Article
Texte intégral: 1 Indice: LILACS Sujet Principal: Acidose tubulaire rénale / Calculs urinaires / Acide citrique Type d'étude: Etiology_studies Limites du sujet: Adult / Female / Humans / Male langue: En Texte intégral: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Thème du journal: BIOLOGIA / MEDICINA Année: 2000 Type: Article