Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum
Braz. j. med. biol. res
;
33(2): 237-40, Feb. 2000. tab
Article
Dans Anglais
| LILACS
| ID: lil-252301
RESUMO
Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in the control of dopamine release. To test this hypothesis, we used a classical model of unilateral selective lesion of these neurons in rats based on 6-hydroxydopamine (6-OHDA) injection into the substantia nigra. Binding of [3H]-GBR 12935, used as a presynaptic marker since it labels specifically the dopamine uptake complex, was dramatically decreased by 83-100 percent in striatum homogenates after 6-OHDA lesion. On the contrary, no reduction of [3H]-ryanodine binding was observed. The present data indicate that [3H]-ryanodine binding sites present in rat striatum are not preferentially localized in dopaminergic terminals
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Dopamine
/
Oxidopamine
/
Agents adrénergiques
/
Canal de libération du calcium du récepteur à la ryanodine
/
Corps strié
/
Syndrome malin des neuroleptiques
/
Neurones
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2000
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS