Effect of n-acetylcysteine in a random skin flap after administration of nicotine, in the rat
Folha méd
;
117(3): 209-11, nov.-dez. 1998. ilus, graf
Article
Dans Anglais
| LILACS
| ID: lil-260507
RESUMO
This study analyzed the perfusion of a random skin flap, after nicotine injection and administration of N-acetylcysteine (NAC). A skin flap was elevated after 6 weeks of nicotine administartion and the percentage of necrosis was determined thereafter, as well as malondialdehyde (MDA) in 4 selected skin areas and in serum. Both nicotine and NAC elicited elevation in MDA levels in the skin samples. Nicotine also led to elevation in serum MDA levels and in the percentage of flap necrosis. NAC did not improve the viability of the flap.
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Indice:
LILAS (Amériques)
Sujet Principal:
Acétylcystéine
/
Lambeaux chirurgicaux
/
Piégeurs de radicaux libres
/
Agonistes nicotiniques
/
Nicotine
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Folha méd
Thème du journal:
Médicament
Année:
1998
Type:
Article
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