Great amount of C.pneumoniae in rupture plaque vessel segments at autopsy: a comparative study with stable plaques
Arq. bras. cardiol
;
74(2): 149-51, Jan. 2000. ilus
Article
Dans Anglais
| LILACS
| ID: lil-262348
ABSTRACT
A possible relationship between C.pneumoniae (CP) infection, atherosclerosis and acute myocardial infarction is a debated matter. Now we performed the search of CP in histological segments of fatal ruptured plaques and of stable plaques by histochemistry (Macchiavello stain), immunohistochemistry and in situ hybridization techniques. Electron microscopy and confocal laser microscopy techniques were used in two additional cases. The semi-quantitification of CP + cells (0-4+) and quantification of lymphocytes demonstrated greater amount of CP + cells and more inflammation in the adventitia of vulnerable plaque vessel segments than of stable ones, larger amount of CP + cells in adventitia than in the plaque and high frequency of CP + cells in all groups studied. This preliminary study strongly suggests a direct pathogenetic involvement of adventitial CP in the rupture of the atheromatous plaque, development of acute myocardial infarction and also in the development of atherosclerosis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Infections à Chlamydia
/
Chlamydophila pneumoniae
/
Athérosclérose
/
Infarctus du myocarde
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Arq. bras. cardiol
Thème du journal:
Cardiologie
Année:
2000
Type:
Article
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