Genomic rearrangements in trypanosomatids: an alternative to the "One Gene" evolutionary hypothesis?
Mem. Inst. Oswaldo Cruz
; 95(4): 527-34, July-Aug. 2000.
Article
de En
| LILACS
| ID: lil-264232
Bibliothèque responsable:
BR1.1
RESUMO
Most molecular trees of trypanosomatids are based on point mutations within DNA sequences. In contrast, there are very few evolutionary studies considering DNA (re) arrangement as genetic characters. Waiting for the completion of the various parasite genome projects, first information may already be obtained from chromosome size-polymorphism, using the appropriate algorithms for data processing. Three illustrative models are presented here. First, the case of Leishmania (Viannia) braziliensis/L. (V.) peruviana is described. Thanks to a fast evolution rate (due essentially to amplification/deletion of tandemly repeated genes), molecular karyotyping seems particularly appropriate for studying recent evolutionary divergence, including eco-geographical diversification. Secondly, karyotype evolution is considered at the level of whole genus Leishmania. Despite the fast chromosome evolution rate, there is qualitative congruence with MLEE- and RAPD-based evolutionary hypotheses. Significant differences may be observed between major lineages, likely corresponding to major and less frequent rearrangements (fusion/fission, translocation). Thirdly, comparison is made with Trypanosoma cruzi. Again congruence is observed with other hypotheses and major lineages are delineated by significant chromosome rearrangements.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Réarrangement des gènes
/
Chromosomes
/
Trypanosomatina
/
Génome de protozoaire
/
Évolution moléculaire
Type d'étude:
Qualitative_research
Limites du sujet:
Animals
langue:
En
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2000
Type:
Article