Vascular Ó1D-Adrenoceptors: Are they related to hypertension?

ABSTRACT

Heterogenic of vascular Ó1D-adrenoceptor subtypes has been revealed by pharmacological and molecular biology studies (i.e., Ó1A- , Ó1B- , and Ó1D-adrenoceptors). The Ó1D-adrenoceptor subtype is predominantly involved in the contraction of a variety of vessels and its role in the control of blood pressure has been suggested, a phenomenon probably related to aging. Recent advances in the use of young pre-hypertensive rats and adult spontaneously hypertensive ratas with one kidney and Grollman-type renal hypertension suggest vascular Ó1D-adrenoceptor involvement in the increased blood pressure. The possible role of Ó1D-adrenoceptors in the genesis/maintenance of hypertension is discussed in this review