Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
Braz. j. med. biol. res
;
33(11): 1343-50, Nov. 2000. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-273209
ABSTRACT
Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40-day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops(r)). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group 2.0 +/- 0.44 pellets and midazolam group 3.60 +/- 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group 2.0 +/- 0.44 pellets and stressed group 4.18 +/- 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/water group 4.18 +/- 0.58 pellets; stressed/midazolam group 3.2 +/- 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Stress psychologique
/
Anxiolytiques
/
Midazolam
/
Saccharose alimentaire
/
Comportement alimentaire
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2000
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal do Rio Grande do Sul/BR
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