Reduçäo da dispersäo do intervalo QTc: potencial mecanismo de proteçäo cardíaca do brometo de piridostigmina / Reduction of QTc interval dispersion: potential mechanism of cardiac protection of pyridostigmine bromide
Arq. bras. cardiol
;
75(3): 205-13, set. 2000. tab, graf
Article
Dans Portugais, Anglais
| LILACS
| ID: lil-274141
ABSTRACT
OBJECTIVE:
Parasympathetic dysfunction is an independent risk factor in individuals with coronary artery disease, and cholinergic stimulation is a potential therapeutical option. We determined the effects of pyridostigmine bromide, a reversible anticholinesterase agent, on electrocardiographic variables of healthy individuals.METHODS:
We carried out a cross-sectional, double blind, randomized, placebo-controlled study. We obtained electrocardiographic tracings in 12 simultaneous leads of 10 healthy young individuals at rest before and after oral administration of 45 mg of pyridostigmine or placebo.RESULTS:
Pyridostigmine increased RR intervals (before 886 + or - 27 ms vs after 1054 + or - 37 ms) and decreased QTc dispersion (before 72 + or - 9ms vs after 45 + or - 3ms), without changing other electrocardiographic variables (PR segment, QT interval, QTc, and QT dispersion).CONCLUSION:
Bradycardia and the reduction in QTc dispersion induced by pyridostigmine may effectively represent a protective mechanism if these results can be reproduced in individuals with cardiovascular diseases.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Bromure de pyridostigmine
/
Anticholinestérasiques
/
Électrocardiographie
/
Coeur
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
/
Portugais
Texte intégral:
Arq. bras. cardiol
Thème du journal:
Cardiologie
Année:
2000
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal Fluminense/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS