Relationship between diversity of hepatitis C quasispecies and histological severity of liver disease
Medicina (B.Aires)
;
60(5/1): 587-90, 2000. tab
Article
Dans Anglais
| LILACS, BINACIS
| ID: lil-275469
RESUMO
The aim of this work to assess in the diversity of hepatitis C virus (HCV) quasispecies is related to histological severity and duration of infection in a cohort of untreated patients with an estimated onset of the disease. A total of 27 patients with diagnosis of chronic liver disease and history of blood transfusion (n = 16) or intravenous drug use (IDU) (n = 11) were included. All were anti-HCV positive and had detectable serum drug injection. Patients who consumed drugs for more than 2 years, or were coinfected with HBV or HIV were excluded. History of alcohol intake (> 80 g/day), ALT level and age at infection were recorded. Histological assessment of grading and staging was performed according to knodell score. The quasispecies diversity was investigated by single strand conformation polymorphism (SSCP) target to HVR-E2 region and SSCP pattern was evaluated as a single or multiple bands. The number of quasispecies did not correlate with estimated duration of the disease. Patients who acquired hepatitis C by blood transfusion did not differ in number of bands from patients who were IDU. There was no correlation between the heterogeneity of HCV quasispecies and age, serum ALT, Knodell score, HAI and fibrosis. In clonclusion the quasiespecies diversity of E2 had no correlation with grade and stage of chronic HCV infection and the presence of quasispecies was independent of the duration of the disease.
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Indice:
LILAS (Amériques)
Sujet Principal:
Variation génétique
/
Hépatite C
/
Hepacivirus
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Medicina (B.Aires)
Thème du journal:
Médicament
Année:
2000
Type:
Article
Pays d'affiliation:
Argentine
Institution/Pays d'affiliation:
Hospital Argerich/AR
/
Universidad de Buenos Aires/AR
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