Stability studies of tolbutamide/ß-cyclodextrin inclusion complexes

RESUMO

The ability of cyclodextrins to encapsulate many molcecules is used to improve the properties of drugs. Complexes of tolbutamide with ß-cyclodextrin were prepared by coprecipitation, kneading and freeze-drying. The inclusion complexes were stored under controlled conditions at 5ºC, 40ºC, 50ºC and 40ºC/75 per cent relative humidity. The influence of temperature and the humidity was examined by performing DSC thermal analysis, X-ray diffractometry, Raman spectroscopy and dissolution rate measurements. The results indicated that the interactions and dissolution rate of TBM/ß-CD inclusion complexes obtained by coprecipitation and kneading were unchanged after storage at 5ºC, 40ºC, 50ºC and 40ºC/75 per cent RH over six months...