Immunomodulatory action of propolis on macrophage activation
J. venom. anim. toxins
;
6(2): 205-19, 2000. graf
Article
Dans Anglais
| LILACS
| ID: lil-276609
RESUMO
Propolis has been the subject of several recent studies, with the aim of elucidating its biological and pharmacological properties. Propolis has a well-known antimicrobial activity as well as antioxidant, antitumoral, antiinflammatory, and regenerative properties, but literature about its effects on the immunes response in scarce. The goal of this work was to evaluate the propolis effect on macrophage activation by oxygen (H2O2) and nitrogen (NO) metabolite determination. Propolis was produced by africanized honeybees and hydroalcoholic solutions were prepared at different concentrations. Peritoneal macrophages were obtained from male BALB/c mice and culture cells were stimulated in vitro with propolis or interferon-gamma (IFN-gamma). In the in vivo assay, the animals were sacrificed after propolis treatment and cells were stimulated with IFN-gamma. We also investigated the co-stimulant action of propolis associated with IFN-gamma on macrophages. The results show that propolis induces a discreet elevation in H2O2 release and a mild inhibition of NO generation, depending on concentration. Propolis had no co-stimulant activity, diminishing IFN-gamma action on H2O2 and NO production. Data suggest that propolis acts on host non-specific immunity by macrophage activation.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Oxygène
/
Propolis
/
Peroxyde d'hydrogène
/
Activation des macrophages
/
Azote
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. venom. anim. toxins
Thème du journal:
Toxicologie
Année:
2000
Type:
Article
Pays d'affiliation:
Brésil
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