Influence of a multideficient diet from northeastern Brazil on resting blood pressure and baroreflex sensitivity in conscious, freely moving rats
Braz. j. med. biol. res
;
34(2): 271-280, Feb. 2001.
Article
Dans Anglais
| LILACS
| ID: lil-281607
ABSTRACT
The "regional basic diet" or RBD is a multideficient diet (providing 8 percent protein) which is known to produce dietary deficiencies in some populations in northeastern Brazil. The present study investigated the effects of RBD-induced malnutrition on resting blood pressure and baroreflex sensitivity in conscious rats. Malnourished rats were obtained by feeding dams the RBD during mating and pregnancy (RBD-1 group) or during nursing and a 10-day period after weaning (RBD-2 group). At 90 days of age, only RBD-2 rats weighed significantly (P<0.001) less than control rats born to dams fed a standard commercial diet (23 percent protein) during pregnancy and nursing. Baseline mean arterial pressure and heart rate of both RBD-1 and RBD-2 rats were comparable to those of controls. The slopes for both reflex bradycardia and tachycardia (bpm/mmHg) induced by intravenous phenylephrine and sodium nitroprusside, respectively, were unchanged in either RBD-1 (-2.08 0.11 and -3.10 0.43, respectively) or RBD-2 (-2.32 0.30 and -3.73 0.53, respectively) rats, when compared to controls (-2.09 0.10 and -3.17 0.33, respectively). This study shows that, after a prolonged period of nutritional recovery, the patterns of resting blood pressure and baroreflex sensitivity of both pre- and postnatally malnourished rats were similar to those of controls. The decreased body weight and the tendency to increased reflex tachycardia in RBD-2 rats may suggest that this type of maternal malnutrition during lactation is more critical than during pregnancy
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pression sanguine
/
Malnutrition protéinocalorique
/
Baroréflexe
/
Régime alimentaire
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Animaux
/
Grossesse
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2001
Type:
Article
/
Congrès et conférence
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Pernambuco/BR
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