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Biological characterization of Trypanosoma cruzi strains
Martínez-Díaz, Rafael A; Escario, José A; Nogal-Ruiz, Juan J; Gómez-Barrio, Alicia.
  • Martínez-Díaz, Rafael A; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva (Parasitología). Madrid. ES
  • Escario, José A; Universidad Complutense de Madrid. Facultad de Farmacia. Departamento de Parasitología. Madrid. ES
  • Nogal-Ruiz, Juan J; Universidad Complutense de Madrid. Facultad de Farmacia. Departamento de Parasitología. Madrid. ES
  • Gómez-Barrio, Alicia; Universidad Complutense de Madrid. Facultad de Farmacia. Departamento de Parasitología. Madrid. ES
Mem. Inst. Oswaldo Cruz ; 96(1): 53-59, Jan. 2001. ilus, tab
Article Dans Anglais | LILACS | ID: lil-281630
RESUMO
Biological parameters of five Trypanosoma cruzi strains from different sources were determined in order to know the laboratory behaviour of natural populations. The parameters evaluated were growth kinetics of epimastigotes, differentiation into metacyclic forms, infectivity in mammalian cells grown in vitro and parasite susceptibility to nifurtimox, benznidazole and gentian violet. Differences in transformation to metacyclic, in the percentage of infected cells as well as in the number of amastigotes per cell were observed among the strains. Regarding to pharmacological assays, Y strain was the most sensitive to the three assayed compounds. These data demonstrate the heterogeneity of natural populations of T. cruzi, the only responsible of infection in humans
Sujets)
Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Trypanosoma cruzi / Génétique des populations Limites du sujet: Animaux langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 2001 Type: Article Pays d'affiliation: Espagne Institution/Pays d'affiliation: Universidad Autónoma de Madrid/ES / Universidad Complutense de Madrid/ES

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Trypanosoma cruzi / Génétique des populations Limites du sujet: Animaux langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 2001 Type: Article Pays d'affiliation: Espagne Institution/Pays d'affiliation: Universidad Autónoma de Madrid/ES / Universidad Complutense de Madrid/ES