Gen supresor de tumores p53 en neoplasias digestivas / p53 tumor supresor gene in digestive cancer
Rev. méd. Chile
;
128(11): 1269-78, nov. 2000. ilus, tab
Article
Dans Espagnol
| LILACS
| ID: lil-282155
RESUMO
Malignant diseases of the digestive tract cause more than 50 percent of deaths due to cancer in Chile. There is a high incidence of gastric and gallbladder cancer and an increasing frequency of colorectal cancer. P53 tumor suppressor gene has a great importance in carcinogenesis and its alterations are specially important in digestive tract tumors such as colorectal cancer. There is contradictory evidence about the frequency of p53 gene or protein alterations or their biological significance. There is little information about p53 in Chile and it is mostly limited to immunohistochemical studies. This revision analyzes the frequency of p53 alterations in digestive tract tumors in Chile, using immunohistochemical and molecular biology methods. A special emphasis is given to the prognostic importance of this gene
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Gènes p53
/
Gènes suppresseurs
/
Tumeurs gastro-intestinales
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2000
Type:
Article
/
descriptif de projet
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