Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
São Paulo med. j
;
119(3): 114-118, May 2001. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-285537
ABSTRACT
CONTEXT Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE:
To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67.DESIGN:
A retrospective study of histological and clinical records.SETTING:
The Heliópolis and Oswaldo Cruz tertiary general hospitals, Säo Paulo. SAMPLE 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS Determination of degree of positivity to paragangliomas via immunohistochemical reactions.RESULTS:
1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100 percent of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias.CONCLUSIONS:
Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Paragangliome
/
Marqueurs biologiques tumoraux
/
Tumeurs de la tête et du cou
/
Protéines tumorales
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
São Paulo med. j
Thème du journal:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Médicament
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Année:
2001
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Hospital Heliópolis/BR
/
Universidade de Säo Paulo/BR
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