Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells
Braz. j. med. biol. res
;
34(6): 699-709, Jun. 2001. ilus, tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-285842
ABSTRACT
The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Endothélium vasculaire
/
Héparine
/
Fibrinolytiques
/
Héparitine sulfate
/
Anticoagulants
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2001
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Säo Paulo/BR
/
Universidade Federal do Rio Grande do Norte/BR
/
Universidade de Mogi das Cruzes/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS