Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins
Braz. j. med. biol. res
;
34(5): 555-566, May 2001. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-285869
ABSTRACT
Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a more complete understanding of the molecular and cellular events governing the formation and actions of endogenous mediators of resolution that appear to control the duration of inflammation. Lipoxins are trihydroxytetraene-containing lipid mediators that can be formed during cell-cell interactions and are predominantly counterregulators of some well-known mediators of inflammation. Since this circuit of lipoxin formation and action appears to be of physiological relevance for the resolution of inflammation, therapeutic modalities targeted at this system are likely to have fewer unwanted side effects than other candidates and current anti-inflammatory therapies. Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Anti-inflammatoires non stéroïdiens
/
Acide acétylsalicylique
/
Acide hydroxyeïcosatétraénoïque
/
Médiateurs de l'inflammation
/
Inflammation
/
Lipides
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2001
Type:
Article
/
descriptif de projet
Pays d'affiliation:
États-Unis d'Amérique
Institution/Pays d'affiliation:
Harvard Medical School/US
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