Fatal evolution of systemic lupus erythematosus associated with Crohn's disease
Arq. gastroenterol
; Arq. gastroenterol;37(4): 224-6, out.-dez. 2000.
Article
de En
| LILACS
| ID: lil-286404
Bibliothèque responsable:
BR1.1
RESUMO
Abstract The authors describe the case of a young Brazilian woman who was treated of ileocolonic Crohn's disease sparing rectum, as confirmed by colonoscopy and histopathological examination. After a 4-years course of sulfasalazine treatment, she presented with skin facial lesions in vespertilio, fever, arthralgias and high titers of anti-ANA and LE cells. A sulfasalazine-induced lupus syndrome was diagnosed, because ofter sulfasalazine withdrawal and a short course of prednisone, the clinical symptoms disappeared and the laboratory tests returned to normal. Mesalazine 3 g/day was started and patient remained well for the next 3 years, when she was again admitted with fever, weakness, arthralgias, diplopy, strabismus and hypoaesthesia in both hands and feet, microhematuria, haematic casts, hypocomplementemia and high titers of autoimmune antibodies. A diagnosis of associated systemic lupus erythematosus was made. Although a pulsotherapy with methylprednisolone was started, no improvement was noticed. A cyclophosphamide trial was tried and again no positive results occurred. The patient envolved to severe clinical manifestation of general vasculitis affecting the central and peripheral nervous system and lungs, havaing a fatal evolution after 2 weeks. Although uncommon, the association of both disease may occur, and the authors call attention to this possibiliti, making a brief review of literature.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Sulfasalazine
/
Maladie de Crohn
/
Anti-inflammatoires non stéroïdiens
/
Mésalazine
/
Lupus érythémateux disséminé
Type d'étude:
Risk_factors_studies
Limites du sujet:
Adult
/
Female
/
Humans
langue:
En
Texte intégral:
Arq. gastroenterol
Thème du journal:
GASTROENTEROLOGIA
Année:
2000
Type:
Article