Efecto de los proteoglicanos arteriales sobre la oxidación in vitro de LDL aislada de pacientes hipercolesterolémicos / Effect of arterial proteoglycans on in vitro oxidation of LDL isolated from hypercholesterolemic patients
Acta cient. venez
;
51(4): 211-22, 2000. tab, graf
Article
Dans Espagnol
| LILACS
| ID: lil-287943
RESUMO
The interaction of LDL with extracellular matrix proteoglycan apparently contribute to the acumulation of apo B-lipoproteins in atherogenesis. Retention of LDL by intima proteoglycans appears to increase the residence time needed for their structural, hydrolytic and oxidative modification. If the rate of LDL entry exceeds the tissue capacity to eliminate the modified products, this process may contribute to atherogenesis. In this study we explored whether alterations of LDL induced by human arterial CSPG alter the lipoprotein susceptibility to copper-catalyzed oxidation. Human LDL was complexed with human arterial CSPG and dissociated by raising the ionic strength. The CSPG-treated LDL was subjected to oxidation by micromolar amounts of copper. This treatment increased LDL susceptibility to oxidation 8 times, as indicated by formation rates of thiobarbituric acid-reacting substances (TBARS). Furthermore, the hypercholesterolemic patients show LDL with significantly higher affinity for arterial proteoglycans than LDL from controls.
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Indice:
LILAS (Amériques)
Sujet Principal:
Protéoglycanes
/
Hypercholestérolémie
/
Lipoprotéines LDL
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Acta cient. venez
Thème du journal:
Science
Année:
2000
Type:
Article
Pays d'affiliation:
Venezuela
Institution/Pays d'affiliation:
Instituto Venezolano de Investigaciones Científicas/VE
/
Universidad Central de Venezuela/VE
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