Significado clínico y frecuencia de la alteración genético/molecular 11q23/MLL en lactantes con leucemia aguda en Chile / Clinical significance and frequency of the 11q23/MLL genetic/molecular alteration in chilean infants with acute leukemia
Rev. méd. Chile
;
129(6): 634-42, jun. 2001. tab, graf
Article
Dans Espagnol
| LILACS
| ID: lil-295392
ABSTRACT
Background:
Acute leukemia (AL) in infants generally shows distinctive biologic features and has a poor prognosis.Aim:
To study the frequency of the cytogenetic alteration of11q23 chromosome or the recombination of MLL gene in infants less than 18 months old, with acute leukemia. Patients andmethods:
We analyzed 37 cases of AL in infants less than 18 months of age diagnosed in Chile from 1989 to 1999. The clinical features and cytogenetic/molecular defects of 11q23MLL gene rearrangement and their influence in prognosis were determined.Results:
There were 18 cases of acute Lymphoblastic leukemia (ALL) characterized by female sex (67 per cent) high presenting leukocyte count (median 99 x109/L), blast cells with a CD10 negative phenotype (50 per cent) and 11q23/MLL rearrangement (39 per cent). Molecular abnormalities of 11q23 were significantly associated with adverse prognosis, with an event free survival (EFS) of only 14 ñ 12 per cent. Interestingly, infants with germ line 11q23 had a very good outcome with an EFS of 73 ñ 11 per cent (p<0.025). There were 19 cases of acute myeloblastic leukemia (AML) characterized by male sex (63 per cent) high leukocyte count (median 93 x 109/L), FAB-MS morphology (53 per cent) and 11q23/MLL rearrangement (53 per cent). EFS was very poor, 20 ñ 9 per cent and 33ñ4 per cent for rearranged and germinal group respectively (p=NS), due to a high mortality rate during the first month of diagnosis.Conclusions:
These findings demonstrate that Chilean ALL infants with 11q23 abnormalities have a very poor prognosis. However those with germinal state can enjoy a prolonged disease free survival with the current treatment protocols
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Chromosomes humains de la paire 11
/
Leucémie aigüe myéloïde
/
Aberrations des chromosomes
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
Type d'étude:
Etude diagnostique
/
Guide de pratique
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Bébé
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2001
Type:
Article
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