Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan
Mem. Inst. Oswaldo Cruz
;
96(7): 997-999, Oct. 2001. graf, tab
Article
Dans Anglais
| LILACS
| ID: lil-298883
ABSTRACT
In this study, the ability of maxadilan and Lutzomyia longipalpis salivary gland lysate to enhance the infection of CBA mice by Leishmania major and of BALB/c mice by L. braziliensis was tested. No difference was observed between sizes of lesion in CBA mice infected with L. major and treated or not with salivary gland lysate or maxadilan, although they were injected in concentrations that induced cutaneous vasodilation. Although parasites were more frequently observed in foot pads and spleens of animals treated with maxadilan than in the animals treated with salivary gland lysate or saline, the differences were small and not statistically significant. The lesions in BALB/c mice infected with L. braziliensis and treated with maxadilan were slightly larger than in animals that received Leishmania alone. Such differences disappeared 14 weeks after infection, and were statistically significant only in one of two experiments
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Psychodidae
/
Extraits tissulaires
/
Vasodilatateurs
/
Leishmaniose cutanée
/
Leishmania
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2001
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fiocruz/BR
/
Secretaria da Saúde do Estado da Bahia/BR
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