Intravascular brachytherapy: a model for the calculation of the dose
Rev. med. nucl. Alasbimn j
;
4(14)2002. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-302575
ABSTRACT
In this study we present the radiation dose distribution for a theoretical model with Montecarlo simulation, and based on an experimental model developed for the study of the prevention of restenosis post-angioplasty employing intravascular brachytherapy. In the experimental in vivo model, the atherosclerotic plaques were induced in femoral arteries of male New Zealand rabbits through surgical intervention and later administration of cholesterol enriched diet. For the intravascular irradiation we employed a 32P source contained within the balloon used for the angioplasty. The radiation dose distributions were calculated using the Monte Carlo code MCNP4B according to a segment of a simulated artery. We studied the radiation dose distribution in the axial and radial directions for different thickness of the atherosclerotic plaques. The results will be correlated with the biologic effects observed by means of histological analysis of the irradiated arteries
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Radio-isotopes
/
Curiethérapie
/
Occlusion du greffon vasculaire
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Rev. med. nucl. Alasbimn j
Thème du journal:
Médecine nucléaire
Année:
2002
Type:
Article
Pays d'affiliation:
Argentine
Institution/Pays d'affiliation:
Dosimetría de Radiaciones Ionizantes/AR
/
Instituto Cardiovascular de Buenos Aires/AR
/
Universidad de Buenos Aires/AR
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