The brain decade in debate: VIII. Peptide hormones and behavior: cholecystokinin and prolactin
Braz. j. med. biol. res
;
34(11): 1369-1377, Nov. 2001.
Article
Dans Anglais
| LILACS
| ID: lil-303326
RESUMO
This article is a transcription of an electronic symposium held on November 28, 2000 in which active researchers were invited by the Brazilian Society of Neuroscience and Behavior (SBNeC) to discuss the advances of the last decade in the peptide field with particular focus on central actions of prolactin and cholecystokinin. The comments in this symposium reflect the diversity of prolactin and cholecystokinin research and demonstrate how the field has matured. Since both peptides play a role in reproductive behaviors, particularly mother-infant interactions, this was the starting point of the discussion. Recent findings on the role of the receptor subtypes as well as interaction with other peptides in this context were also discussed. Another issue discussed was the possible role of these peptides in dopamine-mediated rewarding systems. Both prolactin and cholecystokinin are involved in mechanisms controlling food intake and somatic pain thresholds. The role of peripheral inputs through vagal afferents modulating behavior was stressed. The advent of knockout animals as potential generators of new knowledge in this field was also addressed. Finally, interactions with other neuropeptides and investigation of the role of these peptides in other fields such as immunology were mentioned. Knowledge about the central functions of prolactin and cholecystokinin has shown important advances. The role of these peptides in neurological and psychiatric syndromes such as anorexia, drug abuse and physiological disturbances that lead to a compromised maternal behavior seems relevant
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Prolactine
/
Cholécystokinine
/
Cerveau
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2001
Type:
Article
Pays d'affiliation:
Brésil
/
Israël
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Bar Ilan University/IL
/
Faculdade de Ciências Médicas da Santa Casa de Säo Paulo/BR
/
Tufts University School of Medicine/US
/
Tufts University School of Veterinary Medicine/US
/
Universidade Federal do Rio Grande do Sul/BR
/
Universidade de Säo Paulo/BR
/
University of Minnesota/US
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