Lamivudine therapy for hepatitis B in renal transplantation
Braz. j. med. biol. res
;
35(2): 199-203, Feb. 2002. tab
Article
Dans Anglais
| LILACS
| ID: lil-303547
RESUMO
Antiviral therapies are associated with an increased risk of acute rejection in transplant patients. The aim of the present study was to evaluate the efficacy and safety of lamivudine therapy for hepatitis B virus (HBV) infection in renal transplant patients. Six patients were included in this study. They received 150 mg/day of lamivudine during a follow-up period of 24 months. The laboratory tests monitored were HBV DNA, HBsAg, HBeAg, ALT, gamma-GT, serum creatinine and blood cyclosporine levels. The HBV DNA became undetectable in four patients as early as in the third month of treatment. After six months, the viral load was also negative in the other two patients, and remained so until 18 months of follow-up. The medication was well tolerated with no major side effects. Lamivudine was safe and effective in blocking HBV replication in renal transplant patients without any apparent increase in the risk of graft failure for the 24-month period of study
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Transplantation rénale
/
Inhibiteurs de la transcriptase inverse
/
Lamivudine
/
Rejet du greffon
/
Hépatite B
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Hospital Beneficência Portuguesa de Säo Paulo/BR
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