Cytokine accumulation in osteitis fibrosa of renal osteodystrophy
Braz. j. med. biol. res
;
35(1): 25-29, Jan. 2002. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-304206
ABSTRACT
Bone marrow fibrosis occurs in association with a number of pathological states. Despite the extensive fibrosis that sometimes characterizes renal osteodystrophy, little is known about the factors that contribute to marrow accumulation of fibrous tissue. Because circulating cytokines are elevated in uremia, possibly in response to elevated parathyroid hormone levels, we have examined bone biopsies from 21 patients with end-stage renal disease and secondary hyperparathyroidism. Bone sections were stained with antibodies to human interleukin-1alpha (IL-1alpha), IL-6, IL-11, tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-ß (TGF-ß) using an undecalcified plastic embedding method. Intense staining for IL-1alpha, IL-6, TNF-alpha and TGF-ß was evident within the fibrotic tissue of the bone marrow while minimal IL-11 was detected. The extent of cytokine deposition corresponded to the severity of fibrosis, suggesting their possible involvement in the local regulation of the fibrotic response. Because immunoreactive TGF-ß and IL-6 were also detected in osteoblasts and osteocytes, we conclude that selective cytokine accumulation may have a role in modulating bone and marrow cell function in parathyroid-mediated uremic bone disease
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Ostéite fibrokystique
/
Ostéodystrophie rénale
/
Cytokines
/
Myélofibrose primitive
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Universidade Estadual do Rio de Janeiro/BR
/
Universidade Federal Fluminense/BR
/
Universidade Federal do Rio de Janeiro/BR
/
University of Washington/US
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