Molecular aspects of hepatic carcinogenesis
Rev. Inst. Med. Trop. Säo Paulo
;
44(1): 39-48, Jan.-Feb. 2002. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-307240
RESUMO
Exogenous agents correlated with hepatocellular carcinoma (HCC) have been identified and well characterized. These agents, including the different viruses that cause chronic hepatitis and cirrhosis, can lead to regenerative nodules and dysplastic nodules/adenomatous hyperplasia. These conditions associated with several molecular alterations of hepatocyte ultimately culminate in hepatocellular carcinoma. Recently, there has been a great progress in the identification of somatic and germinative mutations that may be correlated with the development of HCC, justifying a review on the subject. Hence, the factors involved in the process of hepatic carcinogenesis, such as infection by the hepatitis B and C viruses, with a special focus in the molecular alterations described in recent years are discussed herein, pointing out areas potentially relevant for clinical development
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Hépatite C
/
Carcinome hépatocellulaire
/
Hépatite B
/
Tumeurs du foie
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Rev. Inst. Med. Trop. Säo Paulo
Thème du journal:
Médecine tropicale
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
University of Säo Paulo/BR
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