Leptospirosis severity may be associated with the intensity of humoral immune response
Rev. Inst. Med. Trop. Säo Paulo
;
44(2): 79-83, Mar.-Apr. 2002. graf, tab
Article
Dans Anglais
| LILACS, SES-SP
| ID: lil-308010
ABSTRACT
Leptospirosis severity may be increasing, with pulmonary involvement becoming more frequent. Does this increase result from an intense immune response to leptospire? Notice that renal failure, thrombocytopenia and pulmonary complications are found during the immune phase. Thirty-five hospitalized patients with Weil's disease had 5 blood samples drawn, from the 15th day to the 12th month of symptoms, for ELISA-IgM, -IgG and -IgA specific antibody detection. According their 1st IgG titer, the patients were divided into group 1 (n = 13) titer > 1400 (positive) and group 2 (n = 22) titer <=1400 (negative). Early IgG antibodies in group 1 showed high avidity which may indicate reinfection. Group 1 was older, had worse pulmonary and renal function, and fever for a longer period than group 2. Throughout the study, IgG and IgA titers remained higher in group 1. In conclusion, the severity of Weil's disease may be associated with the intensity of the humoral immune response to leptospire
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladie de Weil
/
Affinité des anticorps
/
Production d'anticorps
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Rev. Inst. Med. Trop. Säo Paulo
Année:
2002
Type:
Article
Institution/Pays d'affiliation:
Faculdade de Medicina da Pontifícia Universidade de Säo Paulo/BR
/
Secretaria de Saúde do Estado de Säo Paulo/BR
/
Universidade Federal do Ceará/BR
/
Universidade de Säo Paulo/BR
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