Neurologic complications after heart transplantation
Arq. neuropsiquiatr
;
60(2A): 192-197, June 2002. tab
Article
Dans Anglais
| LILACS
| ID: lil-309208
RESUMO
OBJECTIVE:
Neurologic complications are known as important cause of morbidity and mortality in orthotopic heart transplantation. Our aim was to identify the frequency and outcome of neurologic complications after heart transplantation in a prospective observational study.METHOD:
From September 93 to September 99, as part of our routine heart transplantation protocol all patients with end-stage cardiac failure were evaluated by the same neurologist before and at the time of any neurologic event (symptom or complaint) after transplantation.RESULTS:
Out of 120 candidates evaluated, 62 were successfully transplanted (53 male; median age 45.5 years, median follow-up 26.8 months). Fifteen patients (24 percent) had ischemic, 22 (35 percent) idiopathic, 24 (39 percent) Chagas' disease and 1 (2 percent) had congenital cardiomyopathy. Neurologic complications occurred in 19 patients (31 percent) tremor, severe headache, transient encephalopathy and seizures related to drug toxicity or metabolic changes in 13; peripheral neuropathy in 4; and spinal cord compression in two (metastatic prostate cancer and epidural abscess). No symptomatic postoperative stroke was observed.CONCLUSIONS:
Although frequent, neurologic complications were seldom related to persistent neurologic disability or death. Most of the complications resulted from immunosuppression, however, CNS infection was rare. The absence of symptomatic stroke in our series may be related to the lower frequency of ischemic cardiomyopathy
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Transplantation cardiaque
/
Maladies du système nerveux
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Arq. neuropsiquiatr
Thème du journal:
Neurologie
/
Psychiatrie
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Säo Paulo/BR
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