New enamine derivatives of lapachol and biological activity
An. acad. bras. ciênc
;
74(2): 211-221, June 2002. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-314019
ABSTRACT
A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Naphtoquinones
/
Amines
/
Antinéoplasiques d'origine végétale
Limites du sujet:
Animaux
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
An. acad. bras. ciênc
Thème du journal:
Science
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual do Norte Fluminense/BR
/
Universidade Federal do Ceará/BR
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