Lack of correlation between seminal and plasma HIV-1 viral loads is associated with CD4T cell depletion in therapy-naïve HIV-1+ patients
Mem. Inst. Oswaldo Cruz
;
97(4): 563-567, June 2002. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-314523
ABSTRACT
The present study was conducted to investigate a possible correlation between plasma (PVL) and seminal viral load (SVL) on treatment-naïve HIV-1-infected patients in Vitória, ES, Brazil. We also evaluated whether the progressive immunosuppression associated with HIV disease (as evidenced by declining CD4 T cell counts) has any impact on the correlation between PVL and SVL HIV-1. Viral load on paired blood and semen samples from 56 consecutive treatment-naïve patients were evaluated and compared to CD4 cell counts. Viral load and T cell counts (cells/æl) were determined by NASBA and by flow cytometry, respectively. Overall, a strong positive correlation between PVL and SVL (rho = 0.438, p = 0.001) was observed. However, when patients were grouped according to their CD4 counts, this correlation was only significant among patients with CD4 counts > 200 cells/æl. Results presented here demonstrate the existence of a strong correlation between PVL and SVL on patients with CD4 cell counts > 200 cells/æl, suggesting that this association may correlate with disease progression
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Sperme
/
Infections à VIH
/
Déplétion lymphocytaire
/
Charge virale
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Santa Casa de Misericordia de Vitoria/BR
/
Universidade Federal do Espírito Santo/BR
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