Elevação da gamma-glytamiltransferase sérica na hepatopatia esquistossomótica com a carga parasitária e precede alterações ultra-sonográficas / Serum gamma-glutamyltransferase alteration in hepatic schistosomiasis doesn't correlate with parasitic load and precedes ultrasound alterations
Arq. gastroenterol
;
39(1): 27-31, jan.-mar. 2002. tab
Article
Dans Portugais
| LILACS
| ID: lil-316276
ABSTRACT
Liver disorders are the major manifestations of schistosomiasis mansoni. Factors that account for increased concentrations of cholestasis-indicating enzymes in the hepatosplenic form of the disease are unknown. OBJECTIVE:
To assess the correlation between increased gamma-glutamyltransferase serum levels and both the parasitic load and ultrasound alterations in patients with schistosomiasis. PATIENTS ANDMETHODS:
Twenty-five patients with the chronic form of schistosomiasis were assessed for the presence or absence of increased enzymatic levels, for the parasitic load (low x medium/high) and for ultrasound parameters. Furthermore, analysis of prothrombin time and a platelet count were performed.RESULTS:
Of the 25 patients, 13 showed increased gamma-glutamyltransferase plasma levels. No significant correlation was found between increased gamma-glutamyltransferase levels and the parasitic load, or between increased enzyme levels and ultrasound alterations. Nor did the prothrombin index or the platelet count differ between the two groups (normal gamma-glutamyltransferase levels and increased gamma-glutamyltransferase levels).CONCLUSION:
The parasitic load explains no rise in gamma-glutamyltransferase plasma levels in patients with the chronic form of schistosomiasis, and conventional ultrasound is not a sensitive method to detect the alteration suggested by the increased enzyme level in those patients
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Schistosomiase à Schistosoma mansoni
/
Cholestase intrahépatique
/
Gamma-Glutamyltransferase
/
Parasitoses hépatiques
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Portugais
Texte intégral:
Arq. gastroenterol
Thème du journal:
Gastroentérologie
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federa de São Paulo/BR
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