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Triple therapy with clarithromycin, amoxicillin and omeprazole for Helicobacter pylori eradication in children and adolescents
Kawakami, Elisabete; Ogata, Silvio Kazuo; Portorreal, Áurea C. M; Magni, Ana Maria; Pardo, Mário Luís E; Patrício, Francy R. S.
  • Kawakami, Elisabete; Federal University of São Paulo. Escola Paulista de Medicina. Division of Pediatric Gastroenterology. São Paulo. BR
  • Ogata, Silvio Kazuo; Federal University of São Paulo. Escola Paulista de Medicina. Division of Pediatric Gastroenterology. São Paulo. BR
  • Portorreal, Áurea C. M; Federal University of São Paulo. Escola Paulista de Medicina. Division of Pediatric Gastroenterology. São Paulo. BR
  • Magni, Ana Maria; Santa Casa de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Pardo, Mário Luís E; Federal University of São Paulo. Escola Paulista de Medicina. Division of Pediatric Gastroenterology. São Paulo. BR
  • Patrício, Francy R. S; Federal University of São Paulo. Escola Paulista de Medicina. Department of Medical Pathology. São Paulo. BR
Arq. gastroenterol ; 38(3): 203-206, jul.-set. 2001.
Article Dans Anglais | LILACS | ID: lil-317318
ABSTRACT

BACKGROUND:

Helicobacter pylori infection presents high prevalence in developing countries, but there are few pediatric assays evaluating antimicrobial treatment.

OBJECTIVE:

The aim of this study was to investigate Helicobacter pylori eradication rate using a short regimen (7 and 10 days) of triple therapy with clarithromycin, amoxicillin and omeprazole. PATIENTS AND

METHODS:

Twenty-five Hp positive patients who presented severe epigastralgia, were submitted to antimicrobial treatment with amoxicillin (50 mg/kg/day--maximum dose 1 g bid), clarithromycin (30 mg/kg/day--maximum dose 500 mg bid) and omeprazole (0.6 mg/kg/day--maximum dose 20 mg bid) during 7 or 10 days. After 2 months, clinical symptoms were evaluated and gastric biopsies were taken to test Hp eradication.

RESULTS:

Overall eradication rate was achieved in 16/25 patients (64%--IC(95% = 45-83%), in 11/15 (73%--IC(95%) = 51-95%) patients who used 10 days therapy course and in 5/10 (50%--IC(95%) = 19-81%) who used 7 days therapy course. Eradication drugs were well accepted and adverse effects were reported in two patients (8%).

CONCLUSIONS:

This triple therapy regimen had moderate efficacy (64%). The data suggests that 10 days therapy course achieves better eradication rate (73%) than 7 days course (50%) to treat Hp infection in our population
Sujets)
Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Oméprazole / Helicobacter pylori / Infections à Helicobacter / Clarithromycine / Amoxicilline Type d'étude: Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Mâle langue: Anglais Texte intégral: Arq. gastroenterol Thème du journal: Gastroentérologie Année: 2001 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Federal University of São Paulo/BR / Santa Casa de São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Oméprazole / Helicobacter pylori / Infections à Helicobacter / Clarithromycine / Amoxicilline Type d'étude: Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Mâle langue: Anglais Texte intégral: Arq. gastroenterol Thème du journal: Gastroentérologie Année: 2001 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Federal University of São Paulo/BR / Santa Casa de São Paulo/BR