Influência do acréscimo de manitol à solução nutriente no desempenho mecânico e no grau de edema miocárdico de coraçoes isolados de ratos / Influence of Mannitol Added to the Perfusion Solution on Mechanical Properties and Myocardial Edema of Isolated Rat Hearts
Arq. bras. cardiol
;
64(3): 225-229, Mar. 1995.
Article
Dans Portugais
| LILACS
| ID: lil-319700
ABSTRACT
PURPOSE--To analyse the influence of mannitol added to Krebs-Henseleit (KH) solution on the myocardium edema and myocardial function. METHODS--Isolated rat heart under isovolumetric contractions studied according to Langendorff's technique were perfused with KH solution at constant flow during 90 min. The coronary perfusion pressure, diastolic and systolic pressures were recorded at every 15 min. At the end of the experiment, myocardium water content was measured in hearts perfused with KH solution (group I, n = 9) and in hearts perfused with KH solution plus 8mM mannitol (group II, n = 8). These results were compared to non-perfused control heart (n = 9). RESULTS--Myocardial water content was statistically higher in group I (80.8 +/- 1.3) compared to group II (78.1 +/- 0.7) and control group (75.5 +/- 0.5). Systolic arterial pressure was statistically higher in group I (86.2 +/- 11.5mmHg) compared to group II (72.7 +/- 21.1mmHg). There was no difference in the diastolic pressure between the two groups. Coronary perfusion pressure (Pp) increased progressively during the experiment in both groups. However, Pp was lower in group II than in group I. CONCLUSION--Mannitol added to KH solution significantly attenuates the myocardium edema in the isolated perfused rat heart.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Techniques in vitro
/
Solutions cardioplégiques
/
Diurétiques osmotiques
/
Oedème cardiaque
/
Mannitol
/
Contraction myocardique
Limites du sujet:
Animaux
langue:
Portugais
Texte intégral:
Arq. bras. cardiol
Thème du journal:
Cardiologie
Année:
1995
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual Paulista (UNESP)/BR
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