Isolation of a distally located gene possibly correlated with gametocyte production ability
Mem. Inst. Oswaldo Cruz
;
89(Suppl.2): 33-35, 1994.
Article
Dans Anglais
| LILACS
| ID: lil-319955
RESUMO
Previous studies were focussed on the attempt to correlate observable variations in the size of Plasmodium berghei chromosomes with the loss of ability to produce viable gametocytes. A temporal coincidence between the appearance of a subtelomeric deletion on P. berghei chromosome 5 and the loss of the ability to produce viable gametocytes was observed in a clone (HPE) directly derived from the high gametocyte-producer clone 8417 during mechanical passages. Interestingly enough, three P. berghei sexual-specific genes have already been mapped on internal fragments of this chromosome. A novel gene, clone 150, isolated from a genomic library of clone 8417 using a probe enriched for sexual-specific transcripts, maps on chromosome 5 within 100kb from the telomere. Subtelomeric deletions of chromosome 5 affecting two non-producer clones involve part of the transcribed region of this gene.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Plasmodium berghei
/
Cartographie chromosomique
/
Gènes de protozoaire
/
Gamétogenèse
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
1994
Type:
Article
Pays d'affiliation:
Italie
Institution/Pays d'affiliation:
Istituto Superiore di Sanità/IT
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