Neutralizing antibodies to bovine herpesviruses types 1 (BHV-1) and 5 (BHV-5) induced by an experimental, oil-adjuvanted, BHV-1 vaccine
Braz. j. vet. res. anim. sci
;
38(4): 184-187, 2001. tab
Article
Dans Anglais
| LILACS
| ID: lil-324315
ABSTRACT
An experimental oil-adjuvanted, inactivated vaccine against bovine herpesvirus type 1 (BHV-1.1), was produced and evaluated in its capacity to induce neutralizing antibodies against bovine herpesvirus type 1 (BHV-1, subtypes 1.1 and 1.2) and bovine herpesvirus type 5 (BHV-5). Cattle were vaccinated and revaccinated 90 days later. Antibodies were measured at days 0, 30, 90, 120, 180, 270 and 450 days after the first dose of vaccine (DPV). Antibody titres to BHV-1.1 and BHV-1.2 were significantly higher than to BHV-5 throughout the experiment. While all calves seroconverted to BHV-1.1 and BHV-1.2 after the first dose of vaccine, only two out of 23 (8,7 percent) calves seroconverted to BHV-5. However, after the booster injection all animals seroconverted to the three virus types. At 450 DPV, 79 percent (15/19 cattle) and 84 percent (16/19) were still positive for antibodies to BHV 1.1 and BHV 1.2, whereas 50 percent (10/19) of the calves remained seropositive for BHV-5. It was concluded that although a potent BHV-1 vaccine may induce crossreactive neutralizing antibodies to BHV-5, the levels of such antibodies are significantly lower and of shorter duration than antibodies to BHV-1.1 or BHV-1.2
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Vaccins
/
Herpèsvirus bovin de type 1
/
Herpèsvirus bovin de type 5
/
Anticorps
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. vet. res. anim. sci
Thème du journal:
Médecine vétérinaire
Année:
2001
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fundaçäo Estadual de Pesquisa Agropecuária/BR
/
UUFRGS/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS