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Detection of antibodies to the 97 kDa component of Toxoplasma gondii in samples of human serum
Ribeiro, Alessandra Carla de Almeida; Souza, Maria Aparecida de; Mineo, José Roberto.
  • Ribeiro, Alessandra Carla de Almeida; Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Imunologia. Uberlândia. BR
  • Souza, Maria Aparecida de; Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Imunologia. Uberlândia. BR
  • Mineo, José Roberto; Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Imunologia. Uberlândia. BR
Mem. Inst. Oswaldo Cruz ; 97(7): 1009-1013, Oct. 2002. ilus, tab
Article Dans Anglais | LILACS | ID: lil-325915
RESUMO
This study was carried out to investigate the immune response against 97 kDa (p97) molecular marker of Toxoplasma gondii that has been characterized as a cytosolic protein and a component of the excreted-secreted antigens from this parasite. A total of 60 serum samples from patients were analyzed by enzime-linked immunosorbent assay and Western blot for toxoplasmosis. These samples were organized in three groups, based on clinical symptoms and results of serological tests. Group I 20 samples reactive to IgG and IgM (acute phase); group II 20 non-reactive samples (control group); and group III 20 samples reactive only to IgG (chronic phase). Western blot was performed with total antigenic extracts or with excreted and secreted antigen from T. gondii to identify the fraction correspondent to p97. It was observed that this cytosolic component from T. gondii stimulates the immunologic system to produce both IgM and IgG antibodies in the beginning of the acute infection and IgG throughout the chronic stage of the asymptomatic toxoplasmosis
Sujets)
Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Toxoplasma / Anticorps antiprotozoaires / Protéines de protozoaire / Toxoplasmose Type d'étude: Etude diagnostique / Étude observationnelle Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 2002 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Uberlândia/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Toxoplasma / Anticorps antiprotozoaires / Protéines de protozoaire / Toxoplasmose Type d'étude: Etude diagnostique / Étude observationnelle Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 2002 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Uberlândia/BR