Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats
Arq. neuropsiquiatr
;
60(4): 928-931, Dec. 2002. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-326163
ABSTRACT
Serotonin plays a role at the pathophysiology of depression in humans and in experimental models. The present study investigated the depressive behavior and the weigh evolution in adult rats (60 days) treated from the 1st to the 21st postnatal day with fluoxetine, a selective serotonin reuptake inhibitor (10 mg/kg, sc, daily). The depressive behavior was induced by the forced swim test (FST). The animals were submitted to two sessions of FST 1st session for 15 min and the 2nd session 24h later, for 5 min. During the 2nd session the Latency of the Attempt of Escape (LAE) and Behavioral Immobility (BI) were appraised. The Fluoxetine group when compared to the Control group, showed an increase in LAE and a decrease in BI. The neonatal administration of fluoxetine reduced the depressive behavior in adult rats, possibly by increase in the brain serotonergic activity. This alteration can be associated to process of neuroadaptation
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Natation
/
Comportement animal
/
Fluoxétine
/
Inbiteurs sélectifs de la recapture de la sérotonine
/
Dépression
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Arq. neuropsiquiatr
Thème du journal:
Neurologie
/
Psychiatrie
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
CNPq-PIBIC/BR
/
Universidade Estadual de São Paulo/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade de São Paulo/BR
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