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Antinociceptive effects of Cremophor EL orally administered to mice
Tabarelli, Z; Berlese, D. B; Sauzem, P. D; Mello, C. F; Rubin, M. A.
  • Tabarelli, Z; Universidade Federal de Santa Maria. Centro de Ciências da Saúde. Departamento de Fisiologia. Santa Maria. BR
  • Berlese, D. B; Universidade Federal de Santa Maria. Centro de Ciências Naturais e Exatas. Departamento de Química. Santa Maria. BR
  • Sauzem, P. D; Universidade Federal de Santa Maria. Centro de Ciências Naturais e Exatas. Departamento de Química. Santa Maria. BR
  • Mello, C. F; Universidade Federal de Santa Maria. Centro de Ciências Naturais e Exatas. Departamento de Química. Santa Maria. BR
  • Rubin, M. A; Universidade Federal de Santa Maria. Centro de Ciências Naturais e Exatas. Departamento de Química. Santa Maria. BR
Braz. j. med. biol. res ; 36(1): 119-123, Jan. 2003. graf
Article Dans Anglais | LILACS | ID: lil-326311
RESUMO
Surfactants are frequently used to improve solubilization of lipophilic drugs. Cremophor EL (CrEL) is a polyoxyethylated castor oil surfactant used to solubilize water-insoluble drugs such as anesthetic, antineoplastic, immunosuppressive and analgesic drugs, vitamins and new synthetic compounds, including potential analgesics. The antinociceptive effect of CrEL (3.2, 6.4 and 10.6 g/kg, in 10 ml/kg body weight, by gavage) on the abdominal writhing response induced by intraperitoneal administration of acetic acid (0.8 percent, 10 ml/kg body weight) and on the tail immersion test was investigated in mice. Control animals received castor oil (10 ml/kg body weight) or saline (0.9 percent NaCl, 10 ml/kg body weight). CrEL reduced nociception in a dose-dependent manner in both tests. At 10.6 g/kg, CrEL caused antinociception similar to that induced by dipyrone (300 mg/kg, by gavage) in the abdominal writhing test, and antinociception similar to that induced by morphine (20 mg/kg, by gavage) in the tail immersion test. The effect of castor oil was similar to that of saline in both assays. These data indicate that the appropriate controls should be used when evaluating the effects of potential antinociceptive agents dissolved in CrEL
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Mesure de la douleur / Glycérol / Analgésiques Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2003 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Santa Maria/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Mesure de la douleur / Glycérol / Analgésiques Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2003 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Santa Maria/BR