Comparaçäo do efeito de dois inibidores da HMG CoA redutase sobre a suscetibilidade da LDL à oxidaçäo / Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation
Arq. bras. cardiol
;
80(2): 150-161, Feb. 2003. tab, graf
Article
Dans Portugais, Anglais
| LILACS
| ID: lil-329094
RESUMO
OBJECTIVE:
To study the differences between fluvastatin and pravastatin regarding LDL susceptibility to oxidation, plasma levels of total cholesterol (TC), HDL-C, LDL-C and triglycerides (TG) in hypercholesterolemic patients with established coronary heart disease (CHD).METHODS:
A double-blind randomized parallel study was conducted that included 41 hypercholesterolemic outpatients with CHD treated at the Instituto de Cardiologia do Rio Grande do Sul. The inclusion criteria were LDL-C above 100 mg/dL and triglycerides below 400 mg/dL based on 2 measures. After 4 weeks on a low cholesterol diet, those patients that fullfilled the inclusion criteria were randomized into 2 groups the fluvastatin group (fluvastatin 40 mg/day) and the pravastatin group (pravastatin 20 mg/day), for 24 weeks of treatment. LDL susceptibility to oxidation was analyzed with copper-induced production of conjugated dienes (Cu2+) and water-soluble free radical initiator azo-bis (2'-2'amidinopropanil) HCl (AAPH). Spectroscopy nuclear magnetic resonance was used for determination of lipids.RESULTS:
After 24 weeks of drug therapy, fluvastatin and pravastatin significantly reduced LDL susceptibility to oxidation as demonstrated by the reduced rate of oxidation (azo and Cu) and by prolonged azo-induced lag time (azo lag). The TC, LDL-C, and TG reduced significantly and HDL-C increased significantly. No differences between the drugs were observed.CONCLUSION:
In hypercholesterolemic patients with CHD, both fluvastatin and pravastatin reduced LDL susceptibility to oxidation
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladie des artères coronaires
/
Pravastatine
/
Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase
/
Hypercholestérolémie
/
Indoles
/
Lipoprotéines LDL
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
/
Portugais
Texte intégral:
Arq. bras. cardiol
Thème du journal:
Cardiologie
Année:
2003
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fundaçäo Universitária de Cardiologia/BR
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