Immunogenetic features of steroid-sensitive nephrotic syndrome and focal segmental glomerulosclerosis in brazilian patients of the northeast region of the State of Säo Paulo
Medicina (Ribeiräo Preto)
;
33(1): 47-54, jan.-mar. 2000. tab
Article
Dans Anglais
| LILACS
| ID: lil-331503
ABSTRACT
Steroid-sensitive nephrotic syndrome (SSNS) and focal segmental glomerulosclerosis (FSGC) share immunologic and pathogenetic features. We studied 93 Brazilian patients (46 with SSNS and 47 with FSGC) and 104 control subjects with the objective of characterizing the immunogenetic profile of these varieties of idiopathic nephrotic syndrome. HLA-A, -B, and -DR antigens were typed using a complement-dependent microlymphocytotoxicity assay. No significantly association was observed with HLA-A or -B antigens in either group; however, HLA-B7 and -B12 antigens were increased in SSNS patients. HLA-DR7, -DR1 and the combination of HLA-DR1/DR7 antigens were significantly increased in the total group of patients with SSNS compared to controls or to FGSC patients. The study of only Caucasoid individuals revealed the HLA-DR7 antigen remained significantly increased in SSNS patients. The HLA-B7/DR7 haplotype was significantly increased in both SSNS and FSGC patients. Although the Brazilian population is highly miscigenated, the same antigen (HLA-DR7) which confers susceptibility to SSNS in other Caucasian population is still prevalent in this series
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Indice:
LILAS (Amériques)
Sujet Principal:
Glomérulonéphrite segmentaire et focale
/
Antigènes HLA
/
Syndrome néphrotique
Limites du sujet:
Adolescent
/
Adulte
/
Enfant
/
Enfant d'âge préscolaire
/
Humains
/
Bébé
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Medicina (Ribeiräo Preto)
Thème du journal:
Médicament
Année:
2000
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
USP/BR
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