Delayed administration of G-CSF until day +7 after autologous peripheral blood stem cell transplant is as effective in accelerating hematopoietic as day 0
Rev. invest. clín
;
54(1): 51-56, 2002 Jan-Feb.
Article
Dans Anglais
| LILACS
| ID: lil-332948
RESUMO
PURPOSE:
To compare the hematopoietic recovery and the clinical outcome after high dose chemotherapy and peripheral blood stem cell (PBSC) transplant between patients who received recombinant granulocyte colony-stimulating factor (G-CSF) starting on day 0 and those who received it starting on day +7. PATIENTS ANDMETHODS:
Thirty-five consecutive patients received high dose chemotherapy with ifosfamide, etoposide and carboplatin (ICE) and autologous PBSC transplant. PBSC mobilization was achieved with G-CSF. In 19 transplants done in 1994, G-CSF was started on day 0 and in 16 procedures done in 1995, G-CSF was started on day +7. In both groups G-CSF was given until the absolute neutrophil count was 1 x 10(9)/L.RESULTS:
The median number of days to reach an absolute neutrophil count > 0.1 x 10(9)/L, was 11 in the patients who started the G-CSF on day 0 and 11 days in the patients with delayed administration of G-CSF and to reach > 0.5 x 10(9)/L 14 days and 13 respectively. The median number of days to reach a platelet count > 20 x 10(9)/L was 14 and 13. Comparison of early vs. delayed administration of G-CSF did not show any significant differences regarding the time to achieve platelet independence, number of days with fever, median days of hospital stay, number of red cell or platelet transfusions.CONCLUSIONS:
Starting G-CSF on day +7 after high dose ICE chemotherapy and autologous transplant of PBSC is as effective in restoring the hematopoietic function as is starting its administration on day 0.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protocoles de polychimiothérapie antinéoplasique
/
Facteur de stimulation des colonies de granulocytes
/
Transplantation de cellules souches hématopoïétiques
/
Granulocytes neutrophiles
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Rev. invest. clín
Thème du journal:
Médicament
Année:
2002
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Instituto Nacional de Cancerología/MX
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