Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals

Bongertz, Vera; Ouverney, Elaine Priscilla; Teixeira, Sylvia L. M; Silva-de-Jesus, Carlos; Hacker, Mariana A; Morgado, Mariza G; Bastos, Francisco I

Bongertz, Vera; Ouverney, Elaine Priscilla; Teixeira, Sylvia L. M; Silva-de-Jesus, Carlos; Hacker, Mariana A; Morgado, Mariza G; Bastos, Francisco I.

Bongertz, Vera; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
Ouverney, Elaine Priscilla; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
Teixeira, Sylvia L. M; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
Silva-de-Jesus, Carlos; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
Hacker, Mariana A; Fiocruz. Centro de Informações em Ciência e Tecnologia. Rio de Janeiro. BR
Morgado, Mariza G; Fiocruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro. BR
Bastos, Francisco I; Fiocruz. Centro de Informações em Ciência e Tecnologia. Rio de Janeiro. BR

Mem. Inst. Oswaldo Cruz ; 98(2): 209-212, Mar. 15, 2003. tab, graf

Article Dans Anglais | LILACS | ID: lil-334256

ABSTRACT

ABSTRACT

Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Fragments peptidiques / Anticorps anti-VIH / Protéine d'enveloppe gp41 du VIH / Protéine d'enveloppe gp120 du VIH / Infections à VIH / VIH-1 (Virus de l'Immunodéficience Humaine de type 1) Type d'étude: Étude pronostique Limites du sujet: Femelle / Humains / Mâle langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 2003 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Fiocruz/BR

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