CD34 immunoexpression in penile carcinoma
Acta cir. bras
;
17(supl.3): 12-14, 2002. tab
Article
Dans Anglais
| LILACS
| ID: lil-335010
RESUMO
Objective:
To investigate microvessel density as a risk factor in squamous cell carcinoma of the penis.Methods:
Fifty patients with penile carcinoma were evaluated retrospectively. The mean age and standard deviation were 60.8 +/- 11.8 years. All of them were treated by penectomyand with positive nodes underwent groin lymphadenectomy. Tumor grading was 36 G1 and 24 G2/3. Primary lesion stage was 22pT1 and 28pT2-4. Positive inguinal nodes were observed in 18 patients. Selected paraffin embedded sections were submitted to CD34 immunohistochemical analysis by the avidinbiotin-immunoperoxidase method with antigen retrieval. All slides were examined using an automatic analyser system and the number of micro-vessels in 10 high magnification power fields (400X) were counted in a blind analysis.Results:
Median number of microvessels was 631 in G1 versus 695 in G2/3 tumors (p=0.78), and 696 in pT1 versus 566 pT2-4 tumors (p=0.23). The respective data for pN0 patients was 525 and for pN+ was 696 (p=0.01), which is an unexpected result.Conclusion:
CD34 immunoexpression or microvessel density determined by this method bear no association with tumor grade, stage or prognosis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs du pénis
/
Carcinome épidermoïde
Type d'étude:
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Aged80
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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