Animal model of renal ischemic injury, and chlorpromazine protector effect, evaluated by TC-99M-Mag, dynamic renal scan
Acta cir. bras
;
17(supl.3): 15-19, 2002. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-335011
RESUMO
Acute tubular necrosis(ATN) is a major complication of kidney transplantation, so as of urologic and vascular surgeries. In transplantation, although organ oerfusion with proper solution are feasible and at least partially effective, new approaches remains needed to avoid lost of graft function due to ischemic insults, an by this way, chlorpromazine may play this hole. Sixteen male reats were evaluated by scintigraphy (dynamic renal scan with Tc-99m-MAG3), before and after surgically promote ischemia of left kidney. Animals were divided in 3 groups Group A (control) without ischemic insult; Group B (ischemia without chlorpromazine) and Group C (ischemia with chlorpromazine). Group B demonstrated marked decreased of left renal function, compared with itself (right kidney; p<0,001) and compared with groups A and C (both p<0,001). No statistically observations was noted in group A, that makes sure of non-error source of surgical procedure lonely (p<0,05). Nevertheless mild decrease of left renal function was observed in some animals of group C, these appointments were not statistically significant (p<0,05). Further studies may prove, in the future, its usefulness in humans, specially concerning kidney transplantation.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Chlorpromazine
/
Modèles animaux de maladie humaine
/
Insuffisance rénale
/
Ischémie
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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