Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
Genet. mol. biol
;
25(3): 265-270, Sept. 2002. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-335764
ABSTRACT
Cytogenetic analyses were performed on a bone giant cell reparative granuloma (GCRG) and on three bone giant cell tumors (GCT). The present GCRG case is the second to be described cytogenetically. A modal chromosome number of 46 was observed in all samples. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes 17 and 18. Among the structural anomalies observed, there was preferential involvement of chromosomes 6 and 10. Three GCT cases presented del(10)(p13) and two cases presented del(6)(q25) (1 GCRG and 1 GCT). These breakpoints mapped on 10p and 6q may harbour genes of importance in the development of bone giant cell tumors
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs de la bouche
/
Aberrations des chromosomes
/
Tumeurs à cellules géantes
/
Granulome
Limites du sujet:
Adulte
/
Enfant
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Genet. mol. biol
Thème du journal:
Génétique
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
USP/BR
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