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Human red blood cells from prenatal hemopoiesis. Lithium flux (sodium dependent) asymmetry
Corchs, J. L; Taborda, D; Serrani, R. E.
  • Corchs, J. L; National University of Rosario. School of Medicine. Department of Physiology. Rosario. AR
  • Taborda, D; National University of Rosario. School of Medicine. Department of Physiology. Rosario. AR
  • Serrani, R. E; National University of Rosario. School of Medicine. Department of Physiology. Rosario. AR
Biocell ; 24(3): 233-237, Dec. 2000.
Article Dans Anglais | LILACS | ID: lil-335894
ABSTRACT
In red cells from umbilical cord blood it has been referred the existence of lithium fluxes (contralateral sodium dependent) asymmetry. On account of the relevancy of this transport system in some pathologies it is pertinent the study of its kinetics to relate normal with pathological states in which it is affected. Lithium fluxes--contralateral sodium dependent were determined in N-ethylmaleimide treated neonatal red blood cells. Experimental data were fitted by simple Michaelis-Menten kinetics, finding Km and Vmax variables. It was shown the persistency of asymmetry. The independence of sulfhydryl groups (or the occultation of the groups involved to this inhibitor) could explain asymmetry persistence.
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Indice: LILAS (Amériques) Sujet Principal: Membrane cellulaire / Transport des ions / Sodium-Potassium-Exchanging ATPase / Érythrocytes / Lithium Limites du sujet: Femelle / Humains / Grossesse langue: Anglais Texte intégral: Biocell Thème du journal: C‚lulas Année: 2000 Type: Article Pays d'affiliation: Argentine Institution/Pays d'affiliation: National University of Rosario/AR

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Indice: LILAS (Amériques) Sujet Principal: Membrane cellulaire / Transport des ions / Sodium-Potassium-Exchanging ATPase / Érythrocytes / Lithium Limites du sujet: Femelle / Humains / Grossesse langue: Anglais Texte intégral: Biocell Thème du journal: C‚lulas Année: 2000 Type: Article Pays d'affiliation: Argentine Institution/Pays d'affiliation: National University of Rosario/AR