An experimental model for the transplantation of fetal central nervous system cells to the injured spinal cord in rats
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
57(6): 257-264, Nov.-Dec. 2002. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-336458
RESUMO
INTRODUCTION:
Traumatic spinal cord injury is one of the most disabling conditions occurring in man and thus stimulates a strong interest in its histopathological, biochemical, and functional changes, primarily as we search for preventive and therapeutic methods.PURPOSE:
To develop an experimental model for transplantation of cells from the fetal rat central nervous system to the site of an injured spinal cord of an adult rat in which the transplanted cells survive and become integrated. This experimental model will facilitate investigations of factors that promote regeneration and functional recovery after spinal cord trauma. MATERIAL ANDMETHODS:
Fifteen adult Wistar rats underwent laminectomy, and an spinal cord lesion was made with microdissection. Fetal spinal cord tissue was then transplanted to the site of the injury. The rats were monitored over a 48-hour period, and then their vertebral column was completely removed for histological analysis.RESULTS:
In 60 percent of transplanted rats, the fetal tissue at the injured site remained viable in the site of the lesion
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Moelle spinale
/
Traumatismes de la moelle épinière
/
Transplantation de tissu foetal
/
Transplantation de cellules souches
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Thème du journal:
Médicament
Année:
2002
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
University of Säo Paulo/BR
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