Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
Rev. Soc. Bras. Med. Trop
;
36(3): 335-341, maio-jun. 2003. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-341057
ABSTRACT
The sensitivity of the larval stages of Schistosoma mansoni to chemotherapy with praziquantel and oxamniquine was tested in mice during primary and secondary infections and after different intervals from cercarial exposure. Worm recovery by perfusion of the porto-mesenteric system, followed by counting and a morphometric study of the parasite, allowed the conclusion that the relative resistance of the larval stages of S. mansoni to schistosomicide drugs, demonstrated in primary infections, also persists when the host is already infected. This indicates that a therapeutic failure may result when an infected host is treated some time after being re-infected, because of the presence of migrating, drug-resistant, immature forms of the parasite
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Oxamniquine
/
Praziquantel
/
Schistosoma mansoni
/
Schistosomicides
/
Anthelminthiques
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2003
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fundação Oswaldo Cruz/BR
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