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Co-infecção por Mycoplasma pneumoniae e Chlamydia pneumoniae em placas rotas associadas a infarto agudo do miocardiol / Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction
Higuchi, Maria de Lourdes; Reis, Marcia Martins; Sambiase, Nádia Vieira; Palomino, Suely Aparecida Pinheiro; Castelli, Jussara Bianchi; Gutierrez, Paulo Sampaio; Aiello, Vera Demarchi; Ramires, José Antonio Franchini.
  • Higuchi, Maria de Lourdes; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Reis, Marcia Martins; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Sambiase, Nádia Vieira; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Palomino, Suely Aparecida Pinheiro; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Castelli, Jussara Bianchi; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Gutierrez, Paulo Sampaio; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Aiello, Vera Demarchi; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Ramires, José Antonio Franchini; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
Arq. bras. cardiol ; 81(1): 1-22, July 2003. ilus, tab, graf
Article Dans Portugais, Anglais | LILACS | ID: lil-341301
RESUMO

OBJECTIVE:

To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae).

METHODS:

C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis.

RESULTS:

The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of M. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01).

CONCLUSION:

M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling)
Sujets)
Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Pneumopathie à mycoplasmes / Maladie des artères coronaires / Infections à Chlamydia / Infarctus du myocarde Type d'étude: Facteurs de risque Limites du sujet: Humains langue: Anglais / Portugais Texte intégral: Arq. bras. cardiol Thème du journal: Cardiologie Année: 2003 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Pneumopathie à mycoplasmes / Maladie des artères coronaires / Infections à Chlamydia / Infarctus du myocarde Type d'étude: Facteurs de risque Limites du sujet: Humains langue: Anglais / Portugais Texte intégral: Arq. bras. cardiol Thème du journal: Cardiologie Année: 2003 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR