Síndromes linfoproliferativos crónicos en Chile: estudio prospectivo de 132 casos / Chronic lymphoproliferative disorders in Chile: a prospective study in 132 patients
Rev. méd. Chile
;
131(3): 291-298, mar. 2003. tab
Article
Dans Espagnol
| LILACS
| ID: lil-342316
RESUMO
Background:
Chronic lymphoproliferative disorders include a variety of diseases which are often a diagnostic problem for clinical hematologists.Aim:
To study prospectively the distribution and incidence of chronic lymphoproliferative disorders in Chile and compare them with those of other Western, Latin American and Oriental countries. Patients andmethods:
A group of 132 patients were studied in a 36 months period (1999-2001), with a panel of monoclonal antibodies. A score for chronic lymphocytic leukemia was employed to differentiate it from other B-cell disorders.Results:
The median age was 63 years old (range 32-94). Most patients had B-cell tumors (109) and the rest (23), T-cell tumors (82 percent vs 18 percent). Forty five percent of patients with B-cell tumors had a chronic lymphocytic leukemia (CLL), while the others were disseminated lymphomas. The incidence of T-cell tumors was slightly higher than that of other Western countries. Noteworthy is that the most common of these disorders was adult T cell leukemia/lymphoma (ATLL), in concordance with the high HTLV-1 seroprevalence in Chile.Conclusions:
A morphologic, immunophenotypic and pathological study in a large number of patients with chronic lymphoproliferative disorders in Chile, shows a relatively low incidence of CLL when compared to other chronic B-cell tumors and a high representation of ATLL associated to HTLV-1 infection, compared with other Western countries. The lower incidence of CLL in our study might be due to patient's selection and/or underdiagnosis of this disease as a substantial proportion of CLL are asymptomatic
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Syndromes lymphoprolifératifs
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2003
Type:
Article
Pays d'affiliation:
Chili
/
Royaume-Uni
Institution/Pays d'affiliation:
Royal Marsden Hospital/GB
/
Universidad de Chile/CL
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